Reproductive strategy in mammals

Triorganotin as a compound with potential reproductive toxicity in mammals.

Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including huma...

Aquaporins in the female reproductive system of mammals.

Water and ion accumulation is the driving force for rapid expansion of the amnion and allantois of mammalian placentae during early gestation, and, therefore, essential for embryonic/fetal growth and survival. Aquaporins (AQP) are a family of small integral plasma membrane proteins that primarily transport water across the plasma membrane. To date, thirteen AQP isoforms (AQP 0-12) have been ide...

Great ranging associated with greater reproductive investment in mammals.

Most animals must travel to find food, incurring an unavoidable energy and time cost. Economic theory predicts, and experimental work confirms, that within species, increasing the distance traveled each day to find food has negative fitness consequences, decreasing the amount of energy invested in maintenance, repair, and reproduction. Here, we show that this relationship between daily distance...

Lipotoxicity: impact on oocyte quality and reproductive efficiency in mammals

Lipotoxicity is characterized by excessive saturated fatty acids in the blood, increasing storage in non-adipose cells, which leads to changes in the expression pattern of genes related to endoplasmic reticulum stress (e.g., ATF4, ATF6, CHOP, and GRP78), proand anti-apoptotic pathways (e.g., Bax and Bcl-2, and protein stability, including heat shock proteins, e.g., HSP70). A negative sub-cellul...

Sexual and Reproductive Health Strategy